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创刊20年来，Genome Biology 已经成为该领域中排名最高的开放获取期刊，5年影响因子（5 year IF）从1.45到19.04，累计发文量达6800余篇，篇均引用60余次，累计阅读近3千万次。
从2000到2020，是Genome Biology 的20年，也是基因组学的20年。值此特殊时刻，我们挑选出了过去20年来发表在该期刊上的20篇重要文献，来邀请您一同回顾Genome Biology的二十年，并希望能在未来接收到来自您的稿件。
20周年精选文献回顾
1
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
Research Published on
18 June 2002
Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe and Frank Speleman
2
DAVID: Database for Annotation, Visualization, and Integrated Discovery
Software Published on
14 August 2003
Glynn Dennis Jr, Brad T Sherman, Douglas A Hosack, Jun Yang, Wei Gao, H Clifford Lane and Richard A Lempicki
3
MicroRNA targets in Drosophila
Research Published on
12 December 2003
Anton J Enright, Bino John, Ulrike Gaul, Thomas Tuschl, Chris Sander and Debora S Marks
4
Bioconductor: open software development for computational biology and bioinformatics
Method Published on
15 September 2004
Robert C Gentleman, Vincent J Carey, Douglas M Bates, Ben Bolstad, Marcel Dettling, Sandrine Dudoit, Byron Ellis, Laurent Gautier, Yongchao Ge, Jeff Gentry, Kurt Hornik, Torsten Hothorn, Wolfgang Huber, Stefano Iacus, Rafael Irizarry, Friedrich Leisch…
5
Model-based Analysis of ChIP-Seq (MACS)
Method Published on
17 September 2008
Yong Zhang, Tao Liu, Clifford A Meyer, Jérôme Eeckhoute, David S Johnson, Bradley E Bernstein, Chad Nusbaum, Richard M Myers, Myles Brown, Wei Li and X Shirley Liu
6
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
Software Published on
4 March 2009
Ben Langmead, Cole Trapnell, Mihai Pop and Steven L Salzberg
7
A whole-genome assembly of the domestic cow, Bos taurus
Research Published on
24 April 2009
Aleksey V Zimin, Arthur L Delcher, Liliana Florea, David R Kelley, Michael C Schatz, Daniela Puiu, Finnian Hanrahan, Geo Pertea, Curtis P Van Tassell, Tad S Sonstegard, Guillaume Marçais, Michael Roberts, Poorani Subramanian, James A Yorke and Steven L Salzberg
8
Differential expression analysis for sequence count data
Method Published on
27 October 2010
Simon Anders and Wolfgang Huber
9
Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development
Research Published on
19 August 2011
Marilyn B Renfree, Anthony T Papenfuss, Janine E Deakin, James Lindsay, Thomas Heider, Katherine Belov, Willem Rens, Paul D Waters, Elizabeth A Pharo, Geoff Shaw, Emily SW Wong, Christophe M Lefèvre, Kevin R Nicholas, Yoko Kuroki, Matthew J Wakefield, Kyall R Zenger…
10
The draft genome and transcriptome of Cannabis sativa
Research Published on
20 October 2011
Harm van Bakel, Jake M Stout, Atina G Cote, Carling M Tallon, Andrew G Sharpe, Timothy R Hughes and Jonathan E Page
11
TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
Method Published on
25 April 2013
Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley and Steven L Salzberg
12
DNA methylation age of human tissues and cell types
Study Published on
10 December 2013
Steve Horvath
13
The Kardashian index: a measure of discrepant social media profile for scientists
Comment Published on
30 July 2014
Neil Hall
14
Deletions of chromosomal regulatory boundaries are associated with congenital disease
Research Published on
4 September 2014
Jonas Ibn-Salem, Sebastian Köhler, Michael I Love, Ho-Ryun Chung, Ni Huang, Matthew E Hurles, Melissa Haendel, Nicole L Washington, Damian Smedley, Christopher J Mungall, Suzanna E Lewis, Claus-Eric Ott, Sebastian Bauer, Paul N Schofield, Stefan Mundlos, Malte Spielmann…
15
DNA methylation age of blood predicts all-cause mortality in later life
Research Published on
30 January 2015
Riccardo E Marioni, Sonia Shah, Allan F McRae, Brian H Chen, Elena Colicino, Sarah E Harris, Jude Gibson, Anjali K Henders, Paul Redmond, Simon R Cox, Alison Pattie, Janie Corley, Lee Murphy, Nicholas G Martin, Grant W Montgomery, Andrew P Feinberg…
16
A survey of best practices for RNA-seq data analysis
Review Published on
26 January 2016
Ana Conesa, Pedro Madrigal, Sonia Tarazona, David Gomez-Cabrero, Alejandra Cervera, Andrew McPherson, Michał Wojciech Szcześniak, Daniel J. Gaffney, Laura L. Elo, Xuegong Zhang and Ali Mortazavi
17
Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins
Research Published on
17 May 2017
Rolen M. Quadros, Hiromi Miura, Donald W. Harms, Hisako Akatsuka, Takehito Sato, Tomomi Aida, Ronald Redder, Guy P. Richardson, Yutaka Inagaki, Daisuke Sakai, Shannon M. Buckley, Parthasarathy Seshacharyulu, Surinder K. Batra, Mark A. Behlke, Sarah A. Zeiner, Ashley M. Jacobi…
18
SCANPY: large-scale single-cell gene expression data analysis
Software Published on
6 February 2018
F. Alexander Wolf, Philipp Angerer and Fabian J. Theis
19
The somatic mutation landscape of the human body
Research Published on
24 December 2019
Pablo E. García-Nieto, Ashby J. Morrison and Hunter B. Fraser
20
Hi-D: nanoscale mapping of nuclear dynamics in single living cells
Method Published on
20 April 2020
Haitham A. Shaban, Roman Barth, Ludmila Recoules and Kerstin Bystricky
除了以上20篇精彩内容，今年BMC还推出了【BMC前沿视角】系列内容，邀请编委们及作者们分享科学解读。欢迎点击下方图片浏览来自Genome Biology编委团队的精彩点评：
试试向BMC微信公众号回复【Genome Biology】，一键获取2020年我们发表过的精彩中文解析。
8月30日前，在评论区分享您印象最深的Genome Biology 文章，就有机会获得BMC纪念小鼠公仔一只、纪念小风扇一台、Nature杂志一本。
点击“阅读原文”访问Genome Biology创刊20周年纪念页面。
扩展阅读
【征稿】心理健康研究中的复杂性：理论、方法和经验性贡献 
热烈庆祝Respiratory Research创刊20周年 | 主编寄语
【征稿】饮食对运动表现影响的证据 | BMC期刊联合征稿
COVID-19 下的重症监护和急诊医学 | Springer Nature研究集锦
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