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关键词：风湿科；重点论文；

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做科研、尤其是选题，需要读很多文献；最高效的阅读方式是，先读领域内最受关注的论文。

我们通过大数据分析，找到了神经科及关联疾病在2022年7月发表的论文中，最受关注的论文；希望对同仁们快速了解风湿科研究最新进展有帮助。

如需全文，可加科研助手申请递送，并提供文章编号（仅限3天）。

1，Upadacitinib 用于治疗活动性非放射轴性脊柱关节炎（SELECT-AXIS 2）：一项随机、双盲、安慰剂对照、3 期试验

Deodhar A, et al. Upadacitinib for the treatment of active non-radiographic axial spondyloarthritis (SELECT-AXIS 2): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2022 Jul 30;400(10349):369-379. doi: 10.1016/S0140-6736(22)01212-0. PMID: 35908570.

获取全文请加科研助手，标注“20220811-1”。

2，抗 BDCA2 抗体 Litifilimab 治疗皮肤红斑狼疮的试验

Werth VP, et al. Trial of Anti-BDCA2 Antibody Litifilimab for Cutaneous Lupus Erythematosus. N Engl J Med. 2022 Jul 28;387(4):321-331. doi: 10.1056/NEJMoa2118024. PMID: 35939578.

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3，系统性硬化症相关间质性肺病中促纤维化巨噬细胞的表观遗传调控

Papazoglou A, et al. Epigenetic regulation of profibrotic macrophages in systemic sclerosis- associated interstitial lung disease. Arthritis Rheumatol. 2022 Jul 18. doi: 10.1002/art.42286. Epub ahead of print. PMID: 35849803.

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4，ALPK1 功能获得性突变导致 NF-κB 介导的自身炎症性疾病：ROSAH 综合征患者的功能评估、临床表型和病程

Kozycki CT, et al. Gain-of-function mutations in ALPK1 cause an NF-κB-mediated autoinflammatory disease: functional assessment, clinical phenotyping and disease course of patients with ROSAH syndrome. Ann Rheum Dis. 2022 Jul 22:annrheumdis-2022-222629. doi: 10.1136/annrheumdis-2022-222629. Epub ahead of print. PMID: 35868845.

获取全文请加科研助手，标注“20220811-4”。

5，通过对青少年特发性关节炎的治疗退出进行风险适应分层来预防疾病发作：PREVENT-JIA 试验的结果

Gerss J, et al. Prevention of disease flares by risk-adapted stratification of therapy withdrawal in juvenile idiopathic arthritis: results from the PREVENT-JIA trial. Ann Rheum Dis. 2022 Jul;81(7):990-997. doi: 10.1136/annrheumdis-2021-222029. Epub 2022 Mar 8. PMID: 35260388; PMCID: PMC9209679.

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6，65 岁以上类风湿关节炎患者的低剂量加用泼尼松龙：实用随机、双盲安慰剂对照 GLORIA 试验

Boers M, et al. Low dose, add-on prednisolone in patients with rheumatoid arthritis aged 65+: the pragmatic randomised, double-blind placebo-controlled GLORIA trial. Ann Rheum Dis. 2022 Jul;81(7):925-936. doi: 10.1136/annrheumdis-2021-221957. Epub 2022 May 31. PMID: 35641125; PMCID: PMC9209692.

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‍7，系统性红斑狼疮：新的诊断和治疗方法

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Lazar S, Kahlenberg JM. Systemic Lupus Erythematosus: New Diagnostic and Therapeutic Approaches. Annu Rev Med. 2022 Jul 8. doi: 10.1146/annurev-med-043021-032611. Epub ahead of print. PMID: 35804480.

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8，第二部分：原发性和继发性雷诺现象的处理

Curtiss P, et al. Part II: The Treatment of Primary and Secondary Raynaud's Phenomenon. J Am Acad Dermatol. 2022 Jul 6:S0190-9622(22)02249-6. doi: 10.1016/j.jaad.2022.05.067. Epub ahead of print. PMID: 35809802.